Journal
BIOMOLECULAR ENGINEERING
Volume 22, Issue 1-3, Pages 31-38Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bioeng.2004.09.005
Keywords
(beta alpha)(8)-barrel; TIM-barrel; directed evolution; random mutagenesis
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Natural molecular evolution supplies us with manifold examples of protein engineering. The imitation of these natural processes in the design of new enzymes has led to surprising and insightful results. Well-suited for design by evolutionary methods are enzymes with the common and versatile (beta alpha)(8)-barrel fold. Studies of enzyme stability, folding and design as well as the evolution of (beta alpha)(8)-barrel enzymes are discussed. (C) 2005 Elsevier B.V. All rights reserved.
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