Journal
JOURNAL OF NEUROSCIENCE
Volume 25, Issue 22, Pages 5376-5381Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0766-05.2005
Keywords
oligodendrocyte; postmortem; schizophrenia; DNA methylation; epigenetics; SOX10
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Downregulation of oligodendrocyte-related genes, referred to as oligodendrocyte dysfunction, in schizophrenia has been revealed by DNA microarray studies. Because oligodendrocyte-specific transcription factors regulate the differentiation of oligodendrocytes, genes encoding them are prime candidates for oligodendrocyte dysfunction in schizophrenia. We found that the cytosine-guanine dinucleotide (CpG) island of sex-determining region Y-box containing gene 10 (S0X10), an oligodendrocyte-specific transcription factor, tended to be highly methylated in brains of patients with schizophrenia, correlated with reduced expression of S0X10. We also found that DNA methylation status of S0X10 also was associated with other oligodendrocyte gene expressions in schizophrenia. This may be specific to S0X10, because the CpG island of OLIG2, which encodes another oligodendrocyte-specific transcription factor, was rarely methylated in brains, and the methylation status of myelin-associated oligodendrocytic basic protein, which encodes structural protein in oligodendrocytes, did not account for their expressions or other oligodendrocyte gene expressions. Therefore, DNA methylation status of the S0X10 CpG island could be an epigenetic sign of oligodendrocyte dysfunction in schizophrenia.
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