Study on the role of GABAergic synapses in synchronization

GABAergic synapses play an important role in the control of neural activity as well as the formation of neural circuitry. In particular, the reversal potential of GABAergic synapses can change significantly during development along with the intrinsic neuronal properties. In this report, we study the influence of such synaptic changes on synchrony in neural circuits. We use phase reduction methods to study the stability of synchrony. Numerical simulations of a conductance-based model based on the analysis exhibit the various firing conditions. We also extend the analysis to large globally coupled neuronal networks. (c) 2004 Elsevier B.V. All rights reserved.