Journal
BIOTECHNOLOGY LETTERS
Volume 27, Issue 11, Pages 749-752Publisher
SPRINGER
DOI: 10.1007/s10529-005-5624-y
Keywords
follicle; growth factor; hair growth; keratinocyte
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Keratinocyte growth factor-2 (KGF-2) is found in dermal papilla fibroblasts and its receptor, fibroblast growth factor receptor 2 (FGFR2), in the neighboring outer root sheath of keratinocytes. Administration of recombinant human KGF-2 (rhKGF-2) at 10 ng ml(-1) significantly stimulated human hair-follicle cell proliferation in organ culture (26-35%). Thus, rhKGF-2 is a promising therapeutic agent to stimulate human hair growth.
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