Journal
SEMINARS IN IMMUNOLOGY
Volume 17, Issue 3, Pages 231-237Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2005.02.003
Keywords
memory T cells; naive T cells; cytokines; TCR; peptide/MHC
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It has become clear that the regulation of T cell numbers is under peripheral homeostatic control. However, the rules for homeostasis vary with the T cells' differentiation state and the overall T cell number in the animal. Furthermore, homeostatic pressures can cause unexpected changes in T cell differentiation and function which might promote or dampen T cell reactivity. In this review, we focus on the role of peptide/MHC and cytokine interactions in regulating the size and composition of the T cell pool. (c) 2005 Elsevier Ltd. All rights reserved.
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