Journal
KIDNEY INTERNATIONAL
Volume 67, Issue 6, Pages 2101-2113Publisher
ELSEVIER SCIENCE INC
DOI: 10.1111/j.1523-1755.2005.00316.x
Keywords
pregnancy; HELLP syndrome; angiogenesis; pseudovasculogenesis; VEGF; PIGF; soluble Flt-1; soluble VEGFR-1; proteinuria; edema
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Funding
- NIDDK NIH HHS [DK02825, DK65997, DK64255] Funding Source: Medline
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Preeclampsia is a syndrome that affects 5% of all pregnancies, producing substantial maternal and perinatal morbidity and mortality. The aim of this review is to summarize our current understanding of the pathogenesis of preeclampsia with special emphasis on the recent discovery that circulating anti-angiogenic proteins of placental origin may play an important role in the pathogenesis of proteinuria and hypertension of preeclampsia.
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