Journal
JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS
Volume 44, Issue 6B, Pages 4548-4552Publisher
JAPAN SOC APPLIED PHYSICS
DOI: 10.1143/JJAP.44.4548
Keywords
phase shift; contrast agent; perfluoropentane; nanometer-size particle
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In studying the feasibility of developing tissue-targeted contrast media that can be administered as liquids and vaporized by an external stimulus such as ultrasound, we have investigated the properties of emulsions of nanometer-size particles containing perfluoropentane and 2H,3H-perfluoropentane. We found that the ultrasound intensity required to induce echographically significant vaporization can be controlled by changing the ratio of 2H,3H-perfluoropentane to perfluoropentane and that the intensity threshold increases as this ratio increases. Significant azeotropic phenomena were not observed when the perfluorocarbon mixtures were heated, which indicates that mechanisms other than azotropy are involved in the threshold change. The vaporization of 2H,3H-perfluoropentane may have been due not only to ultrasound energy but also to the energy deposited by ultrasonically induced bubbles of perfluoropentane. Our results might lead to a phase-shift contrast agent with controllable ultrasound energy for phase shifting.
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