Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 95, Issue 3, Pages 488-496Publisher
WILEY
DOI: 10.1002/jcb.20419
Keywords
cadherins; catenins; mammary gland
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Funding
- NCRR NIH HHS [RR18759] Funding Source: Medline
- NIGMS NIH HHS [GM61702, GM51188] Funding Source: Medline
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Cadherin cell-cell adhesion proteins are critical for the formation of tissues from single cells. E-and P-cadherin play important roles in the architecture and function of the normal mammary gland. In breast cancers, the expression, or lack there of, of E-cadherin can differentiate tumor types, whereas the misexpression of either P-cadherin or N-cadherin can be a marker of poor prognosis or increased malignancy, respectively. Additional research is needed to more precisely define the roles of both classical and desmosomal cadherins and their downstream signaling events, in the development and malignant behavior of breast cancers. J. Cell. Biochem. (c) 2005 Wiley-Liss, Inc.
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