Antileishmanial and antifungal activities of xanthanolides isolated from Xanthium macrocarpum

Seven xanthanolides, xanthinosin, xanthatin, 4-hydroxyxanthinosin, xanthinin, 4-epiisoxanthanol, 4-epixanthanol, 2-hydroxyxanthinosin and 4-oxobedfordia acid, were isolated from the fruits of Xanthium macrocatpum. A valuation of the antifungal activity of these xanthanolides against Candida albicans, Candida glabrata and Aspeirgillus fumigatus and of their antileishmanial activity against Leishmania infantum and Leishmania mexicana is presented. (c) 2005 Elsevier B.V. All rights reserved.