Journal
TRENDS IN IMMUNOLOGY
Volume 26, Issue 6, Pages 318-325Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2005.04.003
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It has long been suspected that NF-kappa B signaling has a pivotal role in chronic inflammation-associated malignancies, although genetic evidence for this hypothesis has been lacking. However, recent papers have lent credence to this concept and show that NF-kappa B activation in pre-malignant cells contributes to cell survival and metastatic potential. Furthermore, NF-kappa B activation in tumor-associated leukocytes, especially macrophages, contributes towards tumorigenesis by upregulating tumor-promoting proinflammatory proteins. This emphasizes the importance of NF-kappa B inhibitors as immunotherapeutic agents for chronic inflammation and suggests that these reagents might prevent, or at least inhibit, chronic inflammation-associated tumorigenesis.
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