Journal
JOURNAL OF DERMATOLOGICAL TREATMENT
Volume 16, Issue 3, Pages 158-164Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09546630510041060
Keywords
Clobetasol propionate; plaque-type psoriasis; quality of life; remission; skin atrophy; telangiectasia
Categories
Ask authors/readers for more resources
Background: Various formulations of clobetasol propionate are currently used to treat psoriasis due to its anti-inflammatory, anti-pruritic, vasoconstrictive and immunomodulating properties. Objective: To assess the efficacy, safety and remission profile of clobetasol propionate lotion compared to that of clobetasol propionate emollient cream and lotion vehicle in subjects with moderate to severe plaque-type psoriasis. Methods: Multicentre, investigator-blind, randomized, active and vehicle-controlled, parallel-group study. Results: A total of 192 subjects were treated: 82 with clobetasol propionate lotion, 81 with clobetasol propionate cream and 29 with the vehicle. Clobetasol propionate lotion was significantly more effective than vehicle lotion and was comparable in efficacy to the emollient cream after 4 weeks of treatment. Treatment success was higher for subjects in the clobetasol propionate lotion group than in the emollient cream group after 4 weeks of a treatment-free follow-up period. Clobetasol propionate lotion was safe and well tolerated. Conclusion: The present study demonstrates that clobetasol propionate lotion is an efficacious, safe and well-tolerated alternative to the currently available emollient cream formulation, while showing a better remission profile after 4 weeks of treatment-free follow-up period.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available