Journal
FEBS JOURNAL
Volume 272, Issue 11, Pages 2628-2638Publisher
WILEY
DOI: 10.1111/j.1742-4658.2005.04699.x
Keywords
adhesion molecule; axonal growth cone; cell survival; cytokine; cytoskeleton; mitogen-activated protein kinase; nerve regeneration; neurotrophin; reinnervation; transcription factor
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Peripheral nerve injury is normally followed by a robust regenerative response. Here we describe the early changes associated with injury from the initial rise in intracellular calcium and the subsequent activation of transcription factors and cytokines leading to an inflammatory reaction, and the expression of growth factors, cytokines, neuropeptides, and other secreted molecules involved in cell-to-cell communication promoting regeneration and neurite outgrowth. The aim of this review is to summarize the molecular mechanisms that play a part in executing successful regeneration.
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