Journal
GENE EXPRESSION PATTERNS
Volume 5, Issue 5, Pages 601-608Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.modgep.2005.03.007
Keywords
Xenopus laevis; embryogenesis; Evi-1; kidney; brain; neural crest
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Funding
- NIDDK NIH HHS [5R01DK42932] Funding Source: Medline
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The Evi-1 gene was first identified as a site for viral integration in murine myeloid leukemia. Evi-1 is a zinc finger transcription factor that has been implicated in the development of myeloid neoplasia. In humans, disruption of the Evi-1 locus, by chromosomal rearrangements, is associated with myeloid leukemia and myelodyplastic syndromes. Here, we report the cloning and developmental pattern of expression of Xenopus Evi-1. xEvi-1 is expressed during oogenesis and during embryonic development. In situ hydridization reveals that xEvi-1 has a dynamic expression profile during early embryonic development. Expression of Evi-1 is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck. (c) 2005 Elsevier B.V. All rights reserved.
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