Journal
AGING CELL
Volume 4, Issue 3, Pages 119-125Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1474-9726.2005.00152.x
Keywords
biomarkers; diet; longevity; mice; migration inhibition factor; oxidative stress
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Funding
- NIA NIH HHS [P60 AG008808, P30 AG013283, AG13283, AG08808] Funding Source: Medline
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A diet deficient in the amino acid methionine has previously been shown to extend lifespan in several stocks of inbred rats. We report here that a methionine-deficient (Meth-R) diet also increases maximal lifespan in (BALB/cJ x C57BL/6 J)F1 mice. Compared with controls, Meth-R mice have significantly lower levels of serum IGF-I, insulin, glucose and thyroid hormone. Meth-R mice also have higher levels of liver mRNA for MIF (macrophage migration inhibition factor), known to be higher in several other mouse models of extended longevity. Meth-R mice are significantly slower to develop lens turbidity and to show age-related changes in T-cell subsets. They are also dramatically more resistant to oxidative liver cell injury induced by injection of toxic doses of acetaminophen. The spectrum of terminal illnesses in the Meth-R group is similar to that seen in control mice. Studies of the cellular and molecular biology of methionine-deprived mice may, in parallel to studies of calorie-restricted mice, provide insights into the way in which nutritional factors modulate longevity and late-life illnesses.
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