Journal
APPLIED CLAY SCIENCE
Volume 77-78, Issue -, Pages 52-55Publisher
ELSEVIER
DOI: 10.1016/j.clay.2013.01.016
Keywords
Copper-exchanged montmorillonite; Antibiotic; Diarrhea; Intestinal permeability; Proinflammatory cytokine; Weanling pigs
Funding
- 948 Project, Ministry of Agriculture [2011-G7]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1040]
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The two copper-exchanged montmorillonites (Cu-MMT), Cu2+-exchanged Ca-montmorillonite (Cu*Ca-MMT) and Cu2+-exchanged Na-montmorillonite (Cu*Na-MMT), were used as alternative to chlortetracycline on growth performance, diarrhea, intestinal permeability and proinflammatory cytokine in weanling pigs. Ninety six piglets weaned at 21 +/- 1 d age were allocated to the four groups: (1) control; (2) control + 1.5 g/kg Cu*Ca-MMT; (3) control + 1.5 g/kg Cu*Na-MMT; and (4) control + 75 mg/kg chlortetracycline. The results showed that as compared with the control group, supplementation with Cu*Ca-MMT and Cu*Na-MMT both improved (P < 0.05) average daily gain (ADG) and gain/feed ratio, lowered (P < 0.05) fecal scores and the total viable counts of Clostridium and Escherichia coli in ileum and proximal colon, reduced (P < 0.05) plasma D-lactate and diamine oxidase (DAM, decreased (P < 0.05) interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in ileal mucosal. No difference was observed in the efficiency of the Cu*Ca-MMT group and Cu*Na-MMT group. Supplementation of Cu-MMT was as effective as chlortetracycline for alleviating diarrhea and inflammation, and improving intestinal microflora and mucosal barrier integrity of weanling pigs. The results indicated that Cu-MMT could be a good candidate as an antibiotic alternative in weanling pigs. (C) 2013 Elsevier B.V. All rights reserved.
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