Journal
DEVELOPMENTAL CELL
Volume 8, Issue 6, Pages 915-924Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2005.04.009
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Funding
- NICHD NIH HHS [P01 HD038761, R01HD36081, P01HD38761, R01 HD036081] Funding Source: Medline
- NIGMS NIH HHS [R01 GM067247, P20GM66051, R01GM67247, P20 GM066051] Funding Source: Medline
- NINDS NIH HHS [R01NS29870, R01 NS029870] Funding Source: Medline
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The dorsoventral axis of the Drosophila embryo is patterned by a gradient of bone morphogenetic protein (BMP) ligands. In a process requiring at least three additional extracellular proteins, a broad domain of weak signaling forms and then abruptly sharpens into a narrow dorsal midline peak. Using experimental and computational approaches, we investigate how the interactions of a multiprotein network create the unusual shape and dynamics of formation of this gradient. Starting from observations suggesting that receptor-mediated BMP degradation is an important driving force in gradient dynamics, we develop a general model that is capable of capturing both subtle aspects of gradient behavior and a level of robustness that agrees with in vivo results.
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