4.3 Article

Synthesis of methyl 1-O-(4-hydroxymethamphetaminyl)-α-D-glucopyranouronate

Journal

CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 53, Issue 6, Pages 684-687

Publisher

PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.53.684

Keywords

4-hydroxymethamphetamine; glucuronate; synthesis

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For the purpose of the direct characterization of the intact conjugated form in the urine of a methamphetamine (MA) abuser, 4-hydroxymethamphetamine (4-OHMA) glucuronate, corresponding to one of the metabolites of MA, was synthesized from the commercially available methyl 4-hydroxyphenylacetate.

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