Journal
MICROBES AND INFECTION
Volume 7, Issue 7-8, Pages 1063-1065Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2005.03.026
Keywords
CD4(+)CD25(+) regulatory T cells; FoxP3; HIV
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The immune system faces the difficult task of discerning between foreign, potentially pathogen-derived antigens and self-antigens. Several mechanisms, including deletion of self-reactive T cells in the thymus, have been shown to contribute to the acceptance of self-antigens and the reciprocal reactivity to foreign antigens. Over the last decade it has become increasingly clear that CD4(+)CD25(+) T-Reg cells are crucial for maintenance of T cell tolerance to self-antigens in the periphery, and to avoid development of autoimmune disorders. Recently, evidence has also emerged that demonstrates that CD4(+)CD25(+) T-Reg cells can also suppress T cell responses to foreign pathogens, including viruses such as HIV. In this article we review the current knowledge and potential role of CD4(+)CD25(+) T-Reg cells in HIV infection. (c) 2005 Elsevier SAS. All rights reserved.
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