Journal
NEUROPHARMACOLOGY
Volume 48, Issue 8, Pages 1130-1138Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2004.12.005
Keywords
hypertension; cannabinoids; hemodynamics; cardiac contractility
Categories
Funding
- Intramural NIH HHS [Z01 AA000375-02] Funding Source: Medline
Ask authors/readers for more resources
Cannabinoids and their endogenous and synthetic analogs exert powerful hypotensive and carchodepressor effects by complex mechanisms involving direct and indirect effects on myocardium and vasculature. On the one hand, endocannabinoids and cannabinoid receptors have been implicated in the hypotensive state associated with hemorrhagic, endotoxic and cardiogenic shock, and advanced liver cirrhosis. On the other hand, there is emerging evidence suggesting that the endocannabinergic system plays an important role in the cardiovascular regulation in hypertension. This review is aimed to discuss the in vivo hypotensive and cardiodepressant effects of cannabinoids mediated by cannabinoid and TRPV1 receptors, and focuses on the novel therapeutical strategies offered by targeting the endocannabinoid system in the treatment of hypertension. Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available