Journal
DEVELOPMENTAL CELL
Volume 8, Issue 6, Pages 843-854Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2005.04.010
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Funding
- NCI NIH HHS [CA-16672] Funding Source: Medline
- NIGMS NIH HHS [R01 GM053683, R01 GM52112, R01 GM053683-06S1, R01 GM052112] Funding Source: Medline
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beta-catenin-dependent or canonical Writ signals are fundamental in animal development and tumor progression. Using Xenopus laevis, we report that the BTB/POZ zinc finger family member Kalso directly represses canonical Writ gene targets (Siamois, c-Fos, Cyclin-D1, and c-Myc) in conjunction with TCF/LEF (TCF). Analogous to P-catenin relief of TCF repressive activity, we show that p120-catenin relieves Kaiso-mediated repression of Siamois. Furthermore, Kalso and TCF coassociate, and combined Kaiso and TCF derepression results in pronounced Siamois expression and increased beta-catenin coprecipitation with the Siamois promoter. The functional interdependency is underlined by Kalso suppression of P-catenin-induced axis duplication and by TCF-3 rescue of Kalso depletion phenotypes. These studies point to convergence of parallel p120-catenin/Kaiso and beta-catenin/TCF signaling pathways to regulate gene expression in vertebrate development and possibly carcinogenesis.
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