Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 115, Issue 6, Pages 1431-1439Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI24758
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Funding
- NIDDK NIH HHS [DK049583, U01 DK058026, DK58026, R56 DK049583, R01 DK049583] Funding Source: Medline
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Conventional genetic analysis focuses on the genes that account for specific phenotypes, while traditional epidemiology is more concerned with the environmental causes and risk factors related to traits. Genetic epidemiology is an alliance of the 2 fields that focuses on both genetics, including allelic variants in different populations, and environment, in order to explain exactly how genes convey effects in different environmental contexts and to arrive at a more complete comprehension of the etiology of complex traits. In this review, we discuss the epidemiology of diabetes and the current understanding of the genetic bases of obesity and diabetes and provide suggestions for accelerated accumulation of clinically useful genetic information.
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