Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 93, Issue 6, Pages 1214-1218Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.15-0033
Keywords
-
Funding
- Sao Paulo Research Fecundativo (FAPESP)
- Centro de Estudos Emilio Ribas
Ask authors/readers for more resources
The standard treatment of mucosal leishmaniasis (ML) is pentavalent antimonials, agents with serious adverse effects. Alternative agents include amphotericin B deoxycholate and liposomal amphotericin B. We performed a retrospective study including 29 patients treated with liposomal amphotericin B, most of whom had comorbidities, history of previous treatment of ML, and contraindications to the use of antimonial pentavalent or amphotericin B deoxycholate. We observed a cure rate of 93.1%. Kidney failure was the most important side effect, reported in five patients (17.2%). This study showed a good efficacy and safety profile of liposomal amphotericin B in patients with ML and contraindications to the use of other agents.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available