Inhibin A and activin A may be used to predict pregnancy outcome in women with recurrent miscarriage

Objective: To look at the role of inhibin and activin in predicting pregnancy outcome in patients with history of recurrent miscarriage. Design: Observational clinical Study. Setting: Recurrent miscarriage clinic of a tertiary care teaching hospital. Patient(s): Patients with history of recurrent miscarriage. Intervention(s): Serial serum inhibin A and activin A concentrations were measured in weeks 5 though 8 of pregnancy. Main Outcome Measure(s): Serum concentrations of inhibin A and activin A levels. Result(s): Mean inhibin A concentration at 5 to 6 weeks for women who miscarried and those who had live births was 33 and 51 pg/mL, respectively; activin A at same gestation for the two groups was 534 and 643 pg/mL, respectively. After 2 weeks, mean inhibin A concentration for women who miscarried and those who had live births was 66 and 145 pg/mL, respectively, and activin A was 747 and 1,123 pg/mL, respectively. Conclusion(s): It is possible that inhibin A and activin A may be used as markers to predict pregnancies that are likely to miscarry. (c) 2005 by American Society for Reproductive Medicine.