Journal
PEPTIDES
Volume 26, Issue 6, Pages 1001-1008Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2004.08.033
Keywords
cGMP; vasorelaxation; heart failure; desensitization; phosphorylation
Funding
- NHLBI NIH HHS [R01HL66397, R01 HL066397] Funding Source: Medline
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Natriuretic peptides are a family of hormones/paracrine factors that regulate blood pressure, cardiovascular homeostasis and bone growth. The mammalian family consists of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). A fan-lily of three cell surface receptors mediates their physiologic effects. Two are receptor guanylyl cyclases known as NPR-A/GC-A and NPR-B/GC-B. Peptide binding to these enzymes stimulates the synthesis of the intracellular second messenger, cGMP, whereas a third receptor, NPR-C, lacks enzymatic activity and functions primarily as a clearance receptor. Here, we provide a brief review of how various desensitizing agents and/or conditions inhibit NPR-A and NPR-B by decreasing their phosphorylation state. (c) 2005 Elsevier Inc. All rights reserved.
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