Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 17, Issue 3, Pages 251-256Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2005.04.006
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Funding
- NIGMS NIH HHS [GM58613, R01 GM058613, R01 GM063873, GM063873] Funding Source: Medline
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The universal pre-mRNA processing events of 5' end capping, splicing, and 3' end formation by cleavage/polyadenylation occur co-transcriptionally. As a result, the substrate for mRNA processing factors is a nascent RNA chain that is being extruded from the RNA polymerase II exit channel at 10-30 bases per second. How do processing factors find their substrate RNAs and complete most mRNA maturation before transcription is finished? Recent studies suggest that this task is facilitated by a combination of protein-RNA and protein-protein interactions within a'mRNA factory' that comprises the elongating RNA polymerase and associated processing factors. This 'factory' undergoes dynamic changes in composition as it traverses a gene and provides the setting for regulatory interactions that couple processing to transcriptional elongation and termination.
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