Journal
IMMUNITY
Volume 22, Issue 6, Pages 679-691Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2005.03.015
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Funding
- NHLBI NIH HHS [HL54853] Funding Source: Medline
- NIAID NIH HHS [R01 AI049261, AI49261] Funding Source: Medline
- NIAMS NIH HHS [P30AR48335] Funding Source: Medline
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The polymorphonuclear leukocyte (PMN)-derived serine proteases play a key role in immune complex (IC)-mediated inflammation. However, the mechanisms by which these proteases regulate inflammatory response remain largely undefined. Here, we show that IC-activated cathepsin G- and neutrophil elastase-deficient (CG/NE) PMNs adhered normally to IC-coated surfaces but did not undergo CD11b clustering and failed to initiate cytoskeletal reorganization and cell spreading. As a result, CG/NE-deficient PMNs exhibited severe defects in MIP-2 secretion and reactive oxygen intermediates production. Exogenously added CG, but not proteolytically inactive CG, was sufficient to restore these defects. These findings identify an important role for CG in integrin-dependent PMN effector functions that are separate from and downstream of integrin-dependent adhesion.
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