Journal
TRENDS IN IMMUNOLOGY
Volume 26, Issue 6, Pages 289-291Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2005.03.012
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Although the cause of autoimmune diseases is unknown, it has long been speculated that an infectious agent might have a role in their initiation and progression. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), has been used to study factors in disease pathogenesis. A recent study shows that pertussis toxin, which is used as an adjuvant in EAE, uses Toll-like receptor 4 signaling to mediate its disease-inducing effect.
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