Journal
JOURNAL OF GENERAL VIROLOGY
Volume 86, Issue -, Pages 1669-1679Publisher
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.80806-0
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Funding
- Wellcome Trust Funding Source: Medline
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Human lymphocytes are resistant to genetic modification, particularly from recombinant adenoviruses, thus hampering the analysis of gene function using adenoviral vectors. This study engineered an Epstein-Barr virus-transformed B-lymphoblastoid cell line permissive to adenovirus infection and elucidated key roles for both the coxsackie-adenovirus receptor and alpha v beta 5 integrin in mediating entry of adenoviruses into these cells. The work identified a strategy for engineering B cells to become susceptible to adenovirus infection and showed that such a strategy could be useful for the introduction of genes to alter lymphoblastoid-cell gene expression.
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