Palladium-catalyzed base-selective H-D exchange reaction of nucleosides in deuterium oxide

We have developed an efficient and extensive deuterium incorporation method using a heterogeneous Pd/C-D2O-H-2 System into the base moiety of nucleosides. The results presented here provide a deuterium gas-free, totally catalytic, and post-synthetic deuterium labeling method in D2O media.