Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 33, Issue -, Pages 443-446Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0330443
Keywords
alternative splicing; pre-mRNA splicing; RNA processing; RS domain; small nuclear ribonucleoprotein (RNP)
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Funding
- Medical Research Council [MC_U127584479] Funding Source: researchfish
- MRC [MC_U127584479] Funding Source: UKRI
- Medical Research Council [MC_U127584479] Funding Source: Medline
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SR proteins (serine- and arginine-rich proteins) are an evolutionarily conserved family consisting of essential pre-mRNA splicing factors. Since their discovery and initial characterization, roles of SIR proteins in pre-mRNA splicing and in subsequent steps of post-transcriptional gene expression have expanded significantly. The current hypotheses suggest that SR proteins are multifunctional adaptor molecules that may couple distinct steps of RNA metabolism. in the present study, we will provide an overview of the roles of SR proteins in different steps of post-transcriptional gene expression.
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