Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 163, Issue 1-2, Pages 185-189Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2005.02.016
Keywords
inflammation; microglia/macrophage; Rho-GTPases
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Following spinal cord injury (SCI), neuropathic, chronic pain is a major cause of disability. Recently, glial P2X(4) receptor (P2X(4)R) has been identified as a major contributor to the development of neuropathic pain after peripherial nerve injury. Here we report analysis of P2X(4)R expression following rat SCI. Significant lesional accumulation of P2X(4)R(+) cells was detected as early as 24 It after SCI, reaching maximum cell numbers on Day 7. Thereafter cell numbers declined but persisted at significantly elevated, sub-maximal levels (>70%) until 1 month post injury. Double-immunolabeling identified the majority of lesional P2X(4)R(+) cells as activated microglia/rnacrophages and surviving neurons/neurites. Increase of P2X(4)R(+), beta-APP(+) hypertrophic neurites correlated with proximity to the lesion. Further, P2X(4)R(+) cells coexpressed the intracellular regulators of signalling cascades, COX-1 (>20%), COX-2 (>5%), RhoA (>60%) and RhoB (>10%). (C) 2005 Elsevier B.V. All rights reserved.
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