Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 163, Issue 1-2, Pages 15-23Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2005.01.023
Keywords
neurotrophins; brain-derived neurotrophic factor; hematopoesis; bone marrow stromal cells; neuroimmunology
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In the present study, we demonstrated a significant reduction of B lymphocytes in the blood, spleen and bone marrow of BDNF deficient mice. The observed developmental block in bone marrow B cell development was linked specifically to the Pre-BII stage. B lymphocytes express the BDNF receptors p75(NTR) and TrkB(gp95), while no BDNF expression was found. However, a strong BDNF expression was demonstrated in bone marrow stromal cells. An increase of intracellular free calcium [Ca2+](i) in B lymphocytes after BDNF application confirms a direct responsiveness of B lymphocytes to BDNF. In conclusion, these results suggest a role of BDNF for normal B lymphocyte development through paracrine effects in the bone marrow. (C) 2005 Elsevier B.V. All rights reserved.
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