Journal
ANATOMY AND EMBRYOLOGY
Volume 209, Issue 5, Pages 349-355Publisher
SPRINGER
DOI: 10.1007/s00429-005-0459-9
Keywords
Wnts; neural crest; induction; delamination; differentiation
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The neural crest is a multipotent tissue that originates between the neural epithelium and non-neural ectoderm, which can develop into numerous cell types, including neurons, glia, pigment cells, smooth muscle, cartilage and bone. Work in a variety of animal models has shown that a number of signalling factors are necessary for the induction, delamination and differentiation of neural crest cells. However one family of proteins, the Wnts, shows an overriding influence on this tissue. Here we review recent studies that pinpoint specific roles that Writs play in the development of the neural crest.
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