Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 9, Issue 3, Pages 248-258Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2005.03.006
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Funding
- NCI NIH HHS [CA104685] Funding Source: Medline
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Natural products provide the inspiration for a variety of strategies used in the diversity-oriented synthesis of novel small-molecule libraries. These libraries can be based on core scaffolds from individual natural products, specific substructures found across a class of natural products, or general structural characteristics of natural products. An increasing body of evidence supports the effectiveness of these strategies for identifying new biologically active molecules. Moreover, these efforts have led to significant advances in synthetic organic chemistry. Larger-scale evaluation of these approaches is on the horizon, using screening data that will be made publicly available in the new PubChem database.
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