Journal
JOURNAL OF GAMBLING STUDIES
Volume 21, Issue 2, Pages 179-203Publisher
SPRINGER
DOI: 10.1007/s10899-005-3031-x
Keywords
gambling; genetics; methodology; psychiatric; addiction; twins
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Funding
- NIDA NIH HHS [DA00366, DA04604] Funding Source: Medline
- NIMH NIH HHS [MH60426] Funding Source: Medline
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Twin studies represent an important and powerful approach to estimating the relative contributions of environmental and genetic factors to the expression of psychiatric illnesses. In this article, we first explain the rationale for using large populations of monozygotic and dizygotic twin pairs to estimate genetic and environmental contributions to a disorder and the statistical modeling associated with this approach. We then review results from studies of the Vietnam Era Twin Registry that use this methodology to examine the etiology of pathological gambling ( PG) behaviors. The results provide strong evidence for genetic contributions to the development of PG in men and set the foundation for future studies aimed at identifying the manner in which specific genes and environmental factors individually and in conjunction contribute to PG.
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