Journal
NATURE CELL BIOLOGY
Volume 7, Issue 6, Pages 633-U28Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1265
Keywords
-
Categories
Funding
- NHLBI NIH HHS [HL65572] Funding Source: Medline
- NIA NIH HHS [AG09521, AG20961] Funding Source: Medline
- NICHD NIH HHS [HD18179] Funding Source: Medline
Ask authors/readers for more resources
RNA interference (RNAi) is an important means of eliminating mRNAs, but the intracellular location of RNA-induced silencing complex (RISC) remains unknown. We show here that Argonaute 2, a key component of RISC, is not randomly distributed but concentrates in mRNA decay centres that are known as cytoplasmic bodies. The localization of Argonaute 2 in decay centres is not altered by the presence or absence of small interfering RNAs or their targeted mRNAs. However, RNA is required for the integrity of cytoplasmic bodies because RNase eliminates Argonaute 2 localization. In addition, Argonaute 1, another Argonaute family member, is concentrated in cytoplasmic bodies. These results provide new insight into the mechanism of RNAi function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available