Journal
JOURNAL OF HEALTH SCIENCE
Volume 51, Issue 3, Pages 394-397Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/jhs.51.394
Keywords
fucoidan; cytotoxic T cell; lymphocyte; flow cytometry; mouse
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Male BALB/c mice were administered three fucoidans with different molecular weights prepared from Okinawa mozuku (Cladosiphon okamuranus). The proportion of CD8(+) cells in the spleens of mice fed with high molecular-weight fucoidan significantly increased compared with those in mice fed a control diet. In addition, the CD4(+)/CD8(+) ratio tended to decrease and the proportion of CD11b(+) cells to increase. These results suggest that high molecular-weight fucoidan promotes an increase in the proportion of murine cytotoxic T cells.
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