Journal
FASEB JOURNAL
Volume 19, Issue 8, Pages 875-879Publisher
WILEY
DOI: 10.1096/fj.04-3609hyp
Keywords
embryogenesis; UTR; genomic module; protein coding genes; microRNA gene cluster
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Over the past two decades a variety of mechanisms regulating cellular differentiation have been uncovered. These include signaling by morphogens or membrane-associated ligands and asymmetric segregation of cytoplasmic components. Most of these processes are driven by protein coding genes. Here I describe another possible cellular differentiation mechanism that involves asymmetric segregation of micro RNAs, a group of recently discovered non-protein coding genes that have been shown to be involved in differentiation.-Bentwich, I. A postulated role for microRNA in cellular differentiation.
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