Journal
DEVELOPMENT
Volume 132, Issue 11, Pages 2503-2512Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.01812
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Funding
- Wellcome Trust Funding Source: Medline
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The notochord is the defining structure of the chordates, and has essential roles in vertebrate development. It serves as a source of midline signals that pattern surrounding tissues and as a major skeletal element of the developing embryo. Genetic and embryological studies over the past decade have informed us about the development and function of the notochord. In this review, I discuss the embryonic origin, signalling roles and ultimate fate of the notochord, with an emphasis on structural aspects of notochord biology.
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