Journal
JOURNAL OF BACTERIOLOGY
Volume 187, Issue 11, Pages 3903-3908Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.187.11.3903-3908.2005
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Analysis of unidirectional genomic deletion events and single nucleotide variations suggested that the four subspecies of Francisella tularensis have evolved by vertical descent. The analysis indicated an evolutionary scenario where the highly virulent F. tularensis subsp. tularensis (type A) appeared before the less virulent F. tularensis subsp. holarctica (type B). Compared to their virulent progenitors, attenuated strains of F. tularensis exhibited specific unidirectional gene losses.
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