Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 174, Issue 2, Pages 270-278Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2005.02.012
Keywords
multiple quantum filter; imaging; coherence; inhomogeneity
Funding
- NCI NIH HHS [1R21CA87805] Funding Source: Medline
- NIBIB NIH HHS [1R01EB000291] Funding Source: Medline
- NINDS NIH HHS [1R01NS44818] Funding Source: Medline
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Triple quantum filtered sodium MRI techniques have been recently demonstrated in vivo. These techniques have been previously advocated as a means to separate the sodium NMR signal from different physiological compartments based on the differences between their relaxation rates. Among the different triple quantum coherence transfer filters, the three-pulse coherence transfer filter has been demonstrated to be better suited for human imaging than the traditional four-pulse implementation. While the three-pulse structure has distinct advantages in terms of RF efficiency, the lack of a refocusing pulse in the filter introduces an increased dependence on the main magnetic field inhomogeneities, which can sometimes lead to significant signal loss. In this paper, we characterize these dependencies and introduce a method for their compensation through the acquisition of a B-0 map and the use of a modified phase cycling scheme. (c) 2005 Elsevier Inc. All rights reserved.
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