Journal
PLANTA MEDICA
Volume 71, Issue 6, Pages 535-542Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2005-864155
Keywords
Piper arborescens; Piperaceae; stem; cyclobutanoid amides; piperarborenine; furanoid lignan; (+)-arborone; anti-platelet aggregation activity; cytotoxicity
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Three new cyclobutanoid amides with trans-trans-trans configurations, piperarborenine C, piperarborenine D and piperarborenine E, and a new furanoid lignan, (+)-arborone, together with twelve known compounds, were isolated from the stems of Piper arborescens. The structures of these new compounds were determined by means of spectral analyses. Piperarborenine C, (+)-diayangambin, piplartine, piperolactam B, piperolactam C, aristolactarn Bill, goniothalactam, and methyl trans-3,4,5-trimethoxycinnamate possessed anti-platelet aggregation activity in vitro. Among them, piplartine showed the most potent anti-platelet aggregation activity induced by Collagen and showed an IC50 value of 21.5 mu M. Piperarborenines A-E, piperarborenine, aristololactam BIII and goniothalactam showed significant cytotoxic activity (IC50 values < 4 mu g/mL) against P-388, HT-29 and A549 cell lines in vitro.
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