Journal
NATURE NEUROSCIENCE
Volume 8, Issue 6, Pages 717-719Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1466
Keywords
-
Categories
Funding
- NINDS NIH HHS [NS26150] Funding Source: Medline
Ask authors/readers for more resources
Guidance cues and signal transduction mechanisms acting at the nerve growth cone are fairly well understood, but the intracellular mechanisms operating to change the direction of axon outgrowth remain unknown. We now show that growth cones integrate myosin II - dependent contraction for rapid, coordinated turning at borders of laminin stripes in response to signals from laminin-activated integrin receptors; in the absence of myosin II activity, outgrowth continues across the borders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available