Journal
GENE EXPRESSION PATTERNS
Volume 5, Issue 5, Pages 701-709Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.modgep.2005.02.001
Keywords
notch1; notch4; jagged1; ovary; angiogenesis; follicle; corpus luteum
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Funding
- NHLBI NIH HHS [R01 HL538530] Funding Source: Medline
- NIDDK NIH HHS [5T32DK07328] Funding Source: Medline
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Notch signaling functions to regulate cell-fate decisions by modulating differentiation, proliferation, and survival of cells. Notch receptors and ligands are expressed in embryonic vasculature and are required for the remodeling of the primary embryonic vasculature of mice. Here, we characterize the expression patterns of Notch1, Notch4, and Jagged1 proteins during the process of folliculogenesis and corpus luteum formation in the mouse ovary, an organ with dynamic physiological angiogenic growth. These Notch proteins and ligand are expressed in a subset of ovarian vessels, including both mature ovarian vasculature as well as angiogenic neovessels. Their expression in the ovary was found in both endothelial and vascular associated mural cells. Our data suggest a complex regulatory role for the Notch signaling pathway during mouse oogenesis and ovarian neovascularization. (c) 2005 Elsevier B.V. All rights reserved.
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