Journal
APPLIED RADIATION AND ISOTOPES
Volume 62, Issue 6, Pages 915-918Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2005.01.001
Keywords
rhenium-188; beta-emitter; microspheres; radioactive labeling; radiotherapy
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Intra-arterial infusion of labeled particles is an effective method for local endoradiotherapy of tumors. In this study, we present an efficient method of radiolabeling biodegradable human serum albumin (HSA) microspheres with the short-lived beta-emitter Re-188 using a simple and reliable kit. Up to now, it was not possible to label particles with more than 85-90% efficiency. Under optimized reaction conditions, we achieved nearly 100% uptake of 188Re. Using the proposed kit, we added tartrate solution and increased the pH from 2 to 4-5 after I h reaction time at 95 degrees C. The 188 Re binding to the particles was found to be stable in vitro. 2005 Elsevier Ltd. All rights reserved.
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