Journal
NEUROCOMPUTING
Volume 65, Issue -, Pages 579-586Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.neucom.2004.10.045
Keywords
dopamine; inverted-U-shape property; prefrontal cortex; working memory
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Our on going studies have sought to simulate circuit properties of the mesocortical dopaminergic system. This article describes a reduced model which elucidates the essential nature of dopaminergic modulation in the prefrontal cortex (PFC). Simulating a delayed-response task, we observed that the delay-period activity of the model neurons follows an inverted-U-shaped curve according to the increase in the dopamine level. Subsequent analysis showed that the inverted-U-shaped activation of the model PFC neurons derives from a supercritical pitchfork bifurcation, the formation of which requires synergism between the modulation of the pyramidal-interneuron connection and that of the interneuron's excitability. (c) 2004 Published by Elsevier B.V.
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