Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 161, Issue 1, Pages 169-172Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2005.01.011
Keywords
developing rats; 192 IgG-saporin; ultrasonic vocalisations; homing test
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We analysed the effects of 192 IgG-saporin lesions on pnd 7 upon neonatal behavioural responses. Number of ultrasonic vocalisations (USVs) were recorded on pnds 9, 11 and 13. On pnd 13 rats underwent a homing test to measure olfactory orientation towards nest material. 192 IgG-saporin reduced the number of USVs at all ages considered while increasing number of entrancies into the nest area. These data suggest that early damage to the basal forebrain cholinergic nuclei induces significant changes in the rat behavioural repertoire as early as the second-postnatal week. (c) 2005 Elsevier B.V. All rights reserved.
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