Journal
FEBS LETTERS
Volume 579, Issue 14, Pages 3169-3174Publisher
WILEY
DOI: 10.1016/j.febslet.2005.05.006
Keywords
toxin internalization; mitochondria fusion/fission; cobra cardiotoxin
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Recent advance in understanding the role of toxin proteins in controlling cell death has revealed that pro-apoptotic viral proteins targeting mitochondria contain amphiphilic alpha-helices with pore-forming properties. Herein, we describe that the pore-forming amphiphilic beta-sheet cardiotoxins (or cytotoxins, CTXs) from Taiwan cobra (Naja atra) also target mitochondrial membrane after internalization and act synergistically with CTX-induced cytosolic calcium increase to disrupt mitochondria network. It is suggested that CTX-induced fragmentation of mitochondria play a role in controlling CTX-induced necrosis of myocytes and cause severe tissue necrosis in the victims. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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