Journal
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
Volume 583, Issue 2, Pages 184-188Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrgentox.2005.03.011
Keywords
ELF-EMF exposure; comet assay; different cell types
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The issue of adverse health effects of extremely low-frequency electromagnetic fields (ELF-EMFs) is highly controversial. Contradictory results regarding the genotoxic potential of ELF-EMF have been reported in the literature, To test whether this controversy might reflect differences between the cellular targets examined we exposed Cultured cells derived from different tissues to an intermittent ELF-EMF (50 Hz sinusoidal, 1 mT) for 1-24 h. The alkaline and neutral comet assays were used to assess ELF-EMF-induced DNA strand breaks. We could identify three responder (human fibroblasts, human melanocytes, rat granulosa cells) and three non-responder cell types (human lymphocytes, human monocytes, human skeletal muscle cells), which points to the significance of the cell system used when investigating genotoxic effects of ELF-EMF (c) 2005 Elsevier B.V. All rights reserved.
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