4.8 Article

Efficient protiodesilylation of unactivated C(sp3)-SiMe2Ph bonds using tetrabutylammonium fluoride

Journal

ORGANIC LETTERS
Volume 7, Issue 12, Pages 2405-2408

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol0506821

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Funding

  1. NCI NIH HHS [CA 108191, CA 103507, F32 CA103339, CA 103339, F32 CA103507, F32 CA108191] Funding Source: Medline
  2. NIGMS NIH HHS [R01 GM038907-14, GM 38907, R01 GM038907, R01 GM038907-15] Funding Source: Medline

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[GRAPHICS] The protiodesilylation of unactivated C(sp(3))-SiMe2Ph bonds proceeds efficiently by treatment with tetrabutylammonium fluoride in wet DMF or THF via isolable dimethylsilanol intermediates.

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